Endocrine Abstracts

A 45-year-old female presented with recurrent episodes of neuroglycopaenic symptoms 6 years after Roux-en-Y gastric bypass surgery. Her symptoms occurred during both the fasting and postprandial state. She had a history of Rheumatoid Arthritis. Her symptoms did not response to a complex carbohydrate diet or Acarbose use.Whipple’s triad was demonstrated during a 72 h fast; symptomatic hypoglycaemia (1.8 mmol/l) occurred which resolved with glucose ad...

Introduction: A 28-year-old primigravida developed increasing hairgrowth in androgen sensitive areas in the first trimester of her first pregnancy. She was previously well with menarche at 14 years, normal periods thereafter and no difficulty in conceiving. She took no medication. Clinically, at 34 weeks gestation she had significant hirsutism of her face, arms, legs and a prominent male escutcheon. She was obese but not Cushingoid.Investigations and res...

A 62-year-old male was referred by his GP querying acromegaly. His past medical history included sleep apnoea, hypertension, dislipidaemia and gout. Serum IGF1 was elevated at 827 ug/l (normal range 100–300 ug/l). Prolonged oral glucose tolerance did not show suppression of GH with a nadir of 9.0 mu/l. A pituitary MRI demonstrated a 5x6mm microadenoma. There were no visual field defects. The patient was pre-treated with somatostatin analogues and proceeded to transphenoid...

Primary Carcinoid tumour of Epididymis is a very rare presentation. It accounts to only 0.23% of Carcinoid tumours. Here we present a patient with Primary Carcinoid tumour of Epididymis, which was successfully resected.A 57 year old gentleman with no significant past medical history was seen with painless swelling of his Right testes. He had no symptoms such as weight loss, Diarrhoea or flushing on direct questioning. Examination revealed a Solid, non-te...

Introduction: Levothyroxine is the globally preferred therapeutic compound for primary hypothyroidism. Due to expense and poor efficacy, Liothyronine is not used as first line treatment. This study was formed to answer the ESE’s recent call for data on symptomatic response to Liothyronine and predictors of that response.Method: Patients with failure of symptomatic relief on levothyroxine were invited to try Liothyronine. 23 patients were enrolled. T...

60 year old gentleman referred to endocrine clinic from Rheumatology for raised PTH 23.5 pmol/l, in the context of normal calcium 2.2 mmol/l, low vitamin D 27.3 nmol/l, raised ALP 273 U/l, low phosphate 0.57 mmol/l and normal renal function. Past medical history of hypertension, Barrett’s oesophagus, cluster headaches and previous left femur fracture secondary to motor cross accident. The ALP isoenzyme for bone was raised. He was complaining of backache which he had for s...

Cranial Diabetes Insipidus is a rare diagnosis and rarer still postpartum. We present the case of 24-year-old woman who developed CDI following pregnancy. The patient had developed polydipsia and polyuria 5 months following pregnancy. The pregnancy had been complicated by Gestational Diabetes Mellitus and a large Postpartum Haemorrhage. The patient reported feeling fatigued, lightheaded and she stated a need to drink water frequently: ~ 8 litres throughout the day and 4 litres...

Prolactinomas are a common type of pituitary tumours, making up about 40% of these tumours in total, with an estimated occurrence of 40-50 people per 100, 000. They are more common in women, especially during their reproductive years, but they can affect anyone at any age. Although most prolactinomas are small and respond well to treatment, around 2-10% are aggressive, growing into nearby areas like the cavernous sinus or sphenoid bone. The World Health Organisation’s 201...

Background: There is a strong association between type II diabetes mellitus (DM) and gaining weight. Lifestyle modification is an important factor for weight management to overcome the obesity as well as DM epidemics.Aim of study: To find the differences of eating habits and Rosenberg Self-Esteem between DM patients and control and to find the strongest contributor of risk factors by study groups.Methods: A hospital-based matched c...

Background and aims: Irisin is a novel myokine that promote energy expenditure. It could act on adipocyte metabolism through a novel neural pathway and on the other hand irisin induces neural proliferation and adequate neural differentiation. We aimed to assess serum irisin level in type 2 diabetics (T2DM) and correlate it with metabolic parameters. Also, we assessed the relation between irisin level and diabetic peripheral neuropathy (DPN).Methods: We r...